Clomifene(Clomid) is useful in those who are infertile due to anovulation or oligoovulation. Evidence is lacking for the use of clomifene in those who are infertile without a known reason. In such cases, studies have observed a clinical pregnancy rate 5.6% per cycle with clomifene treatment vs. 1.3%–4.2% per cycle without treatment. Clomifene has also been used with other assisted reproductive technology to increase success rates of these other modalities.
Clomifene citrate is the anti-estrogen of choice for improving recovery of natural production after a cycle, improving production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids.