Anastrozole(Arimidex) Is the first generation of third generation aromatase inhibitors, can be used for the second line in 1995 treatment of advanced breast cancer. Aromatic enzymes belong to the group of cytochrome P450 enzymes involved in steroid biosynthesis. Found in peripheral tissues, including muscle, fat and liver as well as breast tumor cells.
Anastrozole is sometimes used to treat male breast cancer, but has not been well studied in men. Arimidex is being studied for sterile men to balance testosterone levels and maintain healthy sperm counts. Some male athletes and bodybuilders taking anabolic steroids to build muscle also take Arimidex to reduce estrogen production, which is the side effect of steroid use.